St.Luke

St. Luke Medical Technology, Inc. is developing the LUKE Cardiac Monitoring System, a first-in-class implantable cardiac device for continuous ischemia and arrhythmia detection.

LUKE integrates multi-vector sensing, adaptive AI, and cloud-based oversight to enable earlier diagnosis and intervention for cardiac events. With more than 18 million annual global cardiovascular deaths, St. Luke addresses the single greatest unmet need in preventive medicine.

Key Differentiators

Full-Spectrum Detection

Arrhythmia and ischemia via waveform-level ECG analysis.
Patented Multi-Vector Sensing

Multi-angle capture reduces blind spots.
Adaptive AI Personalization

A self-learning engine tailors alerts to each patient.
Validated Real-Time Alerts

Triple-layered review (AI + history + technician) helps ensure accuracy.
10-Year Longevity

Wireless recharging and
ultra-low-power design.
Minimally Invasive Implant

Small, safe, outpatient procedure.

“From AFib to ischemia, one implant covers it all.”

Why LUKE?

A cardiac sentinel that detects arrhythmias and ischemia (including STEMI and NSTEMI) to enable earlier intervention.

Always on and always monitoring

Silent symptoms no longer go unnoticed

Clinician-reviewed AI diagnostics

Faster response = earlier interventions = better outcomes

Pre-Clinical Validation — >99% Correlation Observed

Extensive, repeatable animal testing completed prior to initiation of any human studies

Data Result

• >99% correlation between LUKE multi-vector parasternal ECG and gold-standard 12-lead ECG

• 20+ porcine occulsion study rounds completed to optimize placement and confirm reproducibility

• Across LAD, RCA, and LCX territories, St Luke ICM consistently demonstrated higher ischemia-related signal amplitudes than surface 12-lead ECG, with up to 3.6× signal improvement, most pronounced in LAD and LCX regions

Conclusion

LUKE has completed pre-clinical validation, demonstrating repeatable, high-correlation ECG sensing across clinically relevant coronary territories, supporting readiness for transition toward first-in-human studies.

More than a device — LUKE is peace of mind.
Empower your care team. Protect your future. Trust LUKE.

Important Disclaimers

• The LUKE Cardiac Monitoring System is an investigational device and has not been cleared or approved by the U.S. Food and Drug Administration(FDA).

• The system is not intended to replace emergency medical care. Patients experiencing symptoms such as chest pain, shortness of breath, dizziness, or fainting should seek immediate medical attention.

• Data analysis and alerts are intended to support, not replace, the judgment of qualified healthcare professionals.

• Performance and safety have not yet been established for widespread clinical use.

• Device notifications and data outputs are intended to support clinician decision-making, not to serve as a sole basis for diagnosis or therapyinitiation.

• Patients experiencing acute chest pain, syncope, or related symptoms should seek immediate emergency care independent of device alerts.

Offices

20 S Sarah St. ,

St. Louis, MO 63108

2900 Carskaddon Ave,

Suite 200, Toledo, OH 43606

(314) 502-9417

info@stlukemed.com

By registering, you agree to receive emails from Luke and its trusted partners. View our Terms and Privacy Policy.

Privacy